Ashok Chidambaram
Biologics and Gene Therapy Research Scientist
During his doctoral training he developed a perfusable vascularised heart-on-chip platform, building expertise in iPSC differentiation, organ-on-chip fabrication, live-cell and confocal imaging, and electrophysiology. He subsequently held a postdoctoral position in human toxicology at Bayer Crop Science, where he established multi-organ microfluidic assays for toxicological screening in the context of pesticide-induced Parkinsons Disease. In the Picower Institute at MIT, Oisín performed mechanistic studies on Alzheimer’s Disease pathology in patient-derived cortical organoids, profiled APOE4-associated phenotypes by multi-omic sequencing of post-mortem human brain tissue, and performed functional blood-brain barrier permeability studies in perfusable iPSC brain-on-chip platforms. In CONCEPT, Oisín will contribute to the development and validation of a novel cell therapy for the treatment of Neonatal Ischaemic Encephalopathy.
Our lead team has experience across a range of disciplines and works closely with principal investigators from the wider NIBRT institute